Elevated plasma peptide YY in human neonates versus elevated plasma glucagon-like peptide-1 in adults
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چکیده
منابع مشابه
Stability of glucagon-like peptide 1 and glucagon in human plasma
To investigate the stability of glucagon-like peptide 1 (GLP-1) and glucagon in plasma under short- and long-term storage conditions. Pooled human plasma (n=20), to which a dipeptidyl peptidase 4 (DPP4) inhibitor and aprotinin were added, was spiked with synthetic GLP-1 (intact, 7-36NH2 as well as the primary metabolite, GLP-1 9-36NH2) or glucagon. Peptide recoveries were measured in samples ke...
متن کاملElevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon.
BACKGROUND The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon sh...
متن کاملClinical and Physiological Characterization of Elevated Plasma Glucagon-Like Peptide-1 Levels (Hyperglipemia) in a Dipeptidyl Peptidase IV Mutation Carrier
The clinical application of dipeptidyl peptidase IV inhibitors (DPP4i) increasing active glucagon-like peptide-1 (AGLP-1) levels has been linked to pancreatitis, pancreatic tumors, and cardiovascular events. However, DPP4 mutations in humans or the long-term outcomes of high glucagon-like peptide-1 (GLP-1) level exposure have not been reported. A trio family with a proband showing an extremely ...
متن کاملElevated basal and post-feed glucagon-like peptide 1 (GLP-1) concentrations in the neonatal period.
BACKGROUND Glucagon-like peptide 1 (GLP-1) is an incretin hormone that stimulates glucose-induced insulin secretion, increases beta-cell proliferation, neogenesis and beta-cell mass. In adults, plasma concentrations of amidated GLP-1 are typically within the 5-10 pmol/l range in the fasting state and increases to approximately 50 pmol/l after ingestion of a mixed meal. RESEARCH DESIGN AND MET...
متن کاملEffect of an Acute Incremental Exercise on Plasma Peptide YY, Neuropeptide Y and IGF-1 Concentrations in Young Athletes
This study aims to determine the effect of a single exhausting exercise on plasma PYY, NPY and IGF-1 in young athletes. Thirty-one young athletes (aged 19.52±2.75 years, body mass 79.24±16.13 kg, height 173±6.49 cm, and body fat 16.37±5.92%) volunteered to participate in this study. The participations, in randomized crossover manner, performed a single exercise bout on a cycle ergometer at 50...
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ژورنال
عنوان ژورنال: Biomedical Research
سال: 1998
ISSN: 0388-6107,1880-313X
DOI: 10.2220/biomedres.19.151